The heavy lifting shouldn't be in the UI
My friend Joe Stegman has a few videos on Channel 9 that he made with Robert Scoble. In one he demonstrates the power of the Windows Forms designer in Visual Studio 2005, which allows you to create professional looking applications with relative ease. The new designer lets you spend your time adding value to your application in the "business" layer rather than spending all your time creating the UI.
Take a look...