Just ran across this...
Paul Cornell blogs about "Understanding security and deployment for Visual Studio Tools for Office." http://weblogs.asp.net/vsto/archive/2004/02/05/68400.aspx
It's amazing how much easier it is to use VSTO that it was to use Office Developer. Well, maybe it's not that amazing, because Office Developer sucked. Anyone out there ever try to use Office Developer? I did. Spent about 20 hours with it. Had to be one of the crappiest products any software company ever published.
That said, VSTO is a really good product. And it's getting better. Better integration with Visual Studio.
Anyway, take a read over at Paul's place.